We have an exciting opportunity for a Postdoctoral Researcher to join Dr Johannes Rack’s research team, which focuses on the understanding of the role of ADP-ribosylation signalling in the regulation of the DNA damage response (DDR) of Aspergillus fumigatus. This multidisciplinary project aims to elucidate both the underlying molecular mechanisms as well as the physiological outcomes of ADP-ribosylation signalling on fungal survival, virulence, and diseases progression.  This MRC grant funded post is available from 1 September 2023 until 28 February 2026.

As post-holder you will be responsible for establishing new techniques to manipulate protein levels in vivo and use these tools to characterise proteins involved in the establishment and removal of the ADP-ribosylation signal as well as investigate the downstream effects of DNA damage-induced ADP-ribosylation on DNA repair pathways, fungal viability, and pathogenicity. Experience in Aspergillus cultivation and genetics as well as microscopy are essential, and mouse handling experience is highly desirable. An ability to work collaboratively across the disciplines of microbiology, biochemistry, and structural biology – in particular around DNA repair – would also be an advantage. In addition, you will provide guidance to less experienced members of the research group and assist in research communication, including manuscript writing, conference attendance, and outreach activities. Enthusiasm to creatively think “outside of the box” is much appreciated. This is an ideal post for a candidate looking for a steppingstone to independent PI positions.